There are nine volumes that collect all the comics in this series, which was released over a ten year period. It is very dark and bloody, but sometimes, the funniest moments come in the comics most violent outbursts, and you might end up feeling bad for laughing.
Its got it all: Preachers, angels, voodoo, cults, secret societies, the Saint of Killers, God (yes he is character in the series, and somehow it works), vampires, guns, explosions, stuff blowing up, the myth of Texas, the myth of Ireland, serial killers, and humor.
Basically, the main character, Jessie Custer, unwittingly receives a power equal to God, and in trying to understand this new power, he discovers God has quit his job. Jessie becomes determined to track God down, and make him answer for his actions.
It’s a very entertaining series, but probably not for those easily offended. I would recommend checking out the first volume and seeing if you like it, and going from there. If you read them out of order, the story will not make any sense, though there is a recap at the beginning of each volume after #3, I believe.