Two shows with a somewhat similar premise both get really cool ships a couple of seasons in. One one side we have the USS Defiant, the Federations first ship built primarily for war, commanded by Benjemin Sisko. The other we have The White Star, primarily built from Minbari and Vorlon technology, under the command of John Sheridan.
So who do you think would win, regardless it would be one hell of a fight.