Just played my 5th game of this with my wife. We did the Niska one, which was rough, but once you got a full crew it’s not too hard to avoid getting a warrant, and invoking Niska’s Pound of Flesh rule. We were racing all across the 'verse hiring crew, doing jobs, and trying to keep flying. At one point I had no credits and was down to my last fuel, but was able to finish a job and get paid to keep flying. She beat me by 1 turn… that’s 3 of the 5 wins for her, and the other two were with others and neither of us won them.
We love this game. If you haven’t picked it up yet I recommend it for all fans of the show. I thought this was a good review of the game: http://www.boardgamegeek.com/thread/1134079/firefly-the-game-a-high-level-review